From the Cleveland Clinic, on GLP-1 facial change:
Gauntness, sunken cheeks, new wrinkles and loose skin on the face and neck.
I would be using this serum to tighten my skin even if I weren’t on GLP-1s.
Matrixyl 3000 improved wrinkle-area measures versus placebo in the manufacturer’s split-face study.
Supplier clinical data
What is in it
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The GLP-1 skin support you deserve. Finally.
Clinically backed peptides, put into a triple-peptide, Australian-formulated serum made to help with loose, sagging skin while you’re on a GLP-1.
Join the thousands of women already doing something to look and feel their best while on a GLP-1. No prescription required.
Matrixyl 3000 improved wrinkle-area measures versus placebo in an 8-week split-face study. Supplier clinical data
Matrixyl 3000 + Synthe’6 · Australian-formulated · Vegan and cruelty-free
See the difference or your money back.
30-day money-back guarantee · ships in 48 hours · cancel anytime
A free gift in your first box.
A one-week trial of Steady, our ginger gummies for GLP-1 nausea. Free with your first serum order.
Loose skin is rarely the only thing a GLP-1 brings. Steady is the product our customers add most often, so your first box includes a week of it to try. An $8 value, no code needed.
- Added to every first order automatically
- 7 daily servings, 1 g ginger root extract each
- Keep it or gift it, it is yours either way
The details
What is inside
Matrixyl 3000, a two-peptide complex studied for wrinkle-area and skin-tone measures.
Synthe’6, a third peptide that supports firmness and texture.
Botanical actives: Centella, Kakadu plum, bearberry, and licorice root.
How to use
One to two drops on clean skin, morning and night.
Layer it under SPF in the morning and under your moisturizer at night.
Discontinue if irritation occurs.
Formulation facts
Australian-formulated. Vegan and cruelty-free. Free of parabens and sulfates.
30 mL frosted-glass bottle with dropper, about a 60-day supply.
A topical cosmetic. Not evaluated by the FDA.
Shipping, cancellation, and guarantee
Ships in 48 hours.
Subscriptions renew at $58.50 a month after the 25% first-month offer. Pause or cancel anytime from your account, no phone call required.
Every order is backed by the 30-day money-back guarantee.
Rapid weight loss changes your face.
Losing volume quickly can leave the skin on your face looser and thinner-looking, often before anything else feels different.
“I would be using this serum to tighten my skin even if I weren’t on GLP-1s.”
Customer notes are voluntary feedback from early APLOMB buyers, published with permission. Verified-buyer reviews are collected after every delivery and will appear here as they publish.
The evidence
The serum exists because the peptide data was already strong before GLP-1s made it urgent. Here is what the studies measured, shown plainly.
Deep-wrinkle area after 8 weeks
Matrixyl 3000, split-face study versus placebo
45% less
Deep-wrinkle area indexed to the placebo side at week 8. Sederma clinical data, supplier-funded.
Collagen density after 12 weeks
Matrixyl 3000 peptide complex, versus baseline
+55%
Collagen density indexed to baseline. Sederma clinical data, supplier-funded.
Matrixyl 3000 improved wrinkle-area measures versus placebo in the manufacturer’s split-face study.
Supplier clinical data ↗A 2023 randomized trial of a peptide serum (37 participants) reported firmness and elasticity gains.
Li et al. 2023 ↗In one formula: tripeptide-1, tetrapeptide-7, and tripeptide-38.
Formula facts ↗Peptide studies are small and some are supplier-funded. The serum supports how your skin looks and feels. It is a cosmetic, not a treatment.
The research this page draws on, and where it was published:
The New England Journal of MedicineSTEP 1 trial of semaglutide, 2021 · peer-reviewed
PubMed CentralDermatological profile of GLP-1 therapy, 2025 · peer-reviewed
Journal of Cosmetic DermatologyPeptide serum randomized trial, 2023 · peer-reviewed
Sederma, ParisMatrixyl 3000 and Synthe’6 clinical data · supplier-funded
Hear why this happens, from the person who built the serum.
The medication is doing its job. The problem is speed: fat leaves the face faster than skin can remodel around it. In under a minute, our founder walks through what is actually happening under your skin and what the serum is built to do about it.
Zachary Poll, MSt · Founder
Master's, University of Cambridge
Clinical research, University of Chicago Medicine
1Rapid weight lossThe GLP-1 does its job, and the scale moves fast.
2Facial volume goes firstFat under the skin of the face drops within weeks.
3Skin cannot keep upCollagen rebuilds slower than the volume leaves, so skin reads loose.
4Peptides support the rebuildMatrixyl 3000 and Synthe’6 support collagen where the skin thinned.
Why this serum and not another one.
Most firming products are built for aging skin. On a GLP-1, your skin is not aging faster. It is losing its support structure faster than it can rebuild. That difference is the whole reason this serum exists.
| APLOMB. Facial Serum. | Retinol creams | Generic peptide serums | Waiting it out | |
|---|---|---|---|---|
| Made for the reason GLP-1 skin laxity happens | ✓ | — | — | — |
| Three peptides with published clinical data | ✓ | — | ✓usually one or two | — |
| Gentle enough for thinning skin, AM and PM | ✓ | —irritation is common | ✓ | ✓ |
| Formulated alongside GLP-1 side-effect research | ✓ | — | — | — |
| 30-day money-back guarantee | ✓ | —varies | —varies | — |
| What it costs | $43.87 first month | $20 to $90 | $30 to $120 | Free, while volume keeps dropping |
How directly each option addresses GLP-1 skin laxity
APLOMB. Facial Serum.
Generic peptide serums
Retinol creams
Waiting it out
Read the science for yourself.
We publish the reasoning, not just the product. Start with the article our founder wrote on exactly this issue.
Ozempic Face: What It Is and What Actually Helps
What rapid weight loss does to the dermis, why the change shows up in the face first, and what the peptide evidence does and does not support.
Not sure this is the right product for your symptoms?
The two-minute quiz matches what you are experiencing on your GLP-1 to the right routine. No commitment, and the direct path to buy stays right here.
Take the 2-minute quizWhy I started APLOMB.
“I spent the last ten years as a clinical researcher, a healthcare executive, and a healthcare investor, watching women’s health get overlooked and underinvested in. When GLP-1 telehealth prescriptions exploded, women were being exploited more than ever. I was shocked by how much effort went into profiting off women, and how little went into helping them. That is why I started APLOMB.”
Zachary Poll, MSt · Founder
Master's, University of Cambridge
Clinical research, University of Chicago Medicine
Developed by graduates and employees at
What buyers say.
No published reviews yet. If you have used it, your honest take helps the next person deciding.
Questions, answered
When will I see a difference?
Peptide serums work gradually with daily use. The bottle is built as a roughly 60-day routine, morning and night, so give it consistent weeks rather than days.
Can I use it with my other skincare?
Yes. Layer it under SPF in the morning and under your moisturizer at night. It is free of parabens and sulfates, vegan, and cruelty-free.
Do I need a prescription?
No. Facial Serum is a topical cosmetic you can use alongside your GLP-1 and the rest of your skincare.
How does the subscription work?
Your first month is 25% off, applied automatically at checkout, so the first charge is $43.87. After that it renews at $58.50 a month. Pause or cancel anytime from your account, no phone call required.
What if it is not right for me?
Every order is backed by a 30-day money-back guarantee. Contact us within 30 days for a refund.
Try it for a month on us being wrong.
Every first order is covered by the 30-day money-back guarantee. Subscribe for $43.87 the first month, then $58.50 a month. Cancel or pause anytime.
30-day money-back guarantee · ships in 48 hours · cancel anytime