What the science actually says about the medicine you are on.
Analysis of the GLP-1 literature to help you stay informed.
GLP-1 and Muscle Loss: Why It Happens and What Helps
Up to forty percent of the weight lost on a GLP-1 is lean mass, not fat. Why it happens, why it matters more after fifty, and what actually protects muscle.
How Much Protein You Actually Need on a GLP-1
The standard 0.8 g/kg guideline was set for people who aren't in a deficit. On a GLP-1, the target to preserve muscle is meaningfully higher. Here are the numbers.
Plant vs. Whey Protein for Preserving Muscle
Whey has the reputation, but a head-to-head trial found pea protein built muscle just as well, and for GLP-1 users plant protein has practical advantages too.
The GLP-1 That Skips the Muscle
A third of the weight people lose on a GLP-1 is lean mass. The next generation of these drugs is being engineered around that number.
The Cravings They Did Not Expect to Quiet
Alcohol. Nicotine. Gambling. The trials testing GLP-1s for addictions outside of food are no longer fringe. Here is what they actually show.
Why the Brush Has More Hair Than the Floor
Hair shedding on a GLP-1 is real, common, and almost always brushed off as temporary. The biology is more specific than that, and so is what to do about it.
How Much Weight, and Which Drug
The weight-loss numbers are not the same across these drugs. What each one delivered in its pivotal trial, charted, and why the differences matter less than the marketing.
What the Heart Trial Actually Showed
The biggest thing semaglutide did in its largest trial had nothing to do with weight. It cut heart attacks and strokes in people who had never had diabetes.
The Nausea Has a Shape
The most common reason people stop a GLP-1 is also the most predictable. It tracks the dose, peaks during the climb, and settles. Knowing the shape is most of managing it.
What we cover, and why.
Five beats. Every article belongs to one. Every claim has a citation.
Side effects
One piece per known side effect. The biology, the timeline, what the evidence supports.
The frontier
Non-obesity trials. Addiction. Alzheimer's. PCOS. Liver disease. Sleep apnea. CKD.
New molecules
Retatrutide. CagriSema. Survodutide. Amycretin. What the next generation does differently.
The evidence
Landmark trials walked through in plain language. SURMOUNT. STEP. SELECT. ESSENCE.
Lived experience
Verified buyers, in their own words. Never invented. Always sourced.
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