The GLP-1 side effect support you deserve. Finally.
Clinically-backed products for the side effects of being on GLP-1s. Join the thousands of women already doing something to look and feel their best while on a GLP-1. No prescription required.
Find your expert-backed GLP-1 side-effect routine30-day money-back guarantee · ships in 48 hours
Developed by graduates and employees at
Build
around your
symptoms.
Every product works on its own. Choose one concern or combine the support you need. A complete routine should still feel simple.
What would you like help with?
Choose what you notice and we’ll map the simplest place to start.
Get my expert-backed routineStart with what you notice.
My face looks different.
Support skin as facial volume changes faster than it can remodel.
Meet Facial Serum
I want to protect muscle.
Make 25 grams of plant protein easier to fit into a smaller appetite.
Meet Protein
My hair is shedding.
Give the body iron, vitamin D, and zinc during rapid weight loss.
Meet Roots
Nausea is running the day.
Build ginger root extract and vitamin B6 into a simple routine.
Meet SteadyChoose your kit.
Complete System.
$204 bought separatelyAll fourSerum, Protein, Roots, and Steady.
Build the Complete System →Free gift in your first box
Subscription savings are applied automatically at checkout. Every first order also carries a free one-week trial of the sister gummy, a $9 value. 30-day money-back guarantee · ships in 48 hours · no subscription required to buy
What customers and clinicians are saying.
Customer notes are voluntary feedback from early APLOMB buyers, published with permission. Clinical excerpts link to their original published sources and describe the side-effect problem; they are not endorsements of APLOMB products.
A free gift in your first box.
A one-week trial of the sister gummy, free with every first order.
The side effects rarely arrive one at a time, so your first box includes a week of the companion gummy to try alongside whatever you start with. A $9 value, no code needed.
- Added to every first order automatically
- 7 daily servings, one for each day of the first week
- Keep it or gift it, it is yours either way
−45%
deep-wrinkle surface area at 8 weeks.
From a supplier-funded dossier on the peptide blend, measured in a general dermal-aging population. It shows what the active can do; it does not prove the same result on GLP-1 skin specifically.
See the study record and APLOMB’s interpretation
1.76×
the odds of new hair shedding at 12 months.
A large observational analysis found higher odds of telogen effluvium among GLP-1 users. Observational data can show an association; it cannot prove that the medication alone caused the shedding.
See the study record and APLOMB’s interpretation
44%
reported nausea on semaglutide in STEP-1.
Trial participants are monitored differently than everyday users, and most episodes were mild-to-moderate, a median of 8 days. A figure like this describes a population, not your Tuesday.
See the study record and APLOMB’s interpretation
up to 40%
of the weight lost can be lean mass.
From a DXA body-composition substudy of STEP-1. The reported range is wide — a quarter to forty percent — and it depends on protein intake, resistance training, and age.
See the study record and APLOMB’s interpretation
Why APLOMB?
| APLOMB. The system. | Piecemeal supplements | Clinic & spa add-ons | Waiting it out | |
|---|---|---|---|---|
| Made for the way GLP-1 side effects actually happen | ✓ | — | — | — |
| Covers face, hair, stomach, and muscle in one routine | ✓ | —one symptom per bottle | —one concern per visit | — |
| Third-party tested | ✓ | —varies | — | — |
| No appointments, no prescriptions | ✓ | ✓ | — | ✓ |
| 30-day money-back guarantee | ✓ | —varies | — | — |
| What it costs | From $35kits from $99 | $60–$120across four bottles | $80–$300a visit | Freewhile it compounds |
How completely each option covers the four GLP-1 side effects
Why I started APLOMB.
“I spent the last ten years as a clinical researcher, a healthcare executive, and a healthcare investor, watching women’s health get overlooked and underinvested in. When GLP-1 telehealth prescriptions exploded, women were being exploited more than ever. I was shocked by how much effort went into profiting off women, and how little went into helping them. That is why I started APLOMB.”
Zachary Poll, MSt · Founder
Master's, University of Cambridge
Clinical research, University of Chicago Medicine
Questions, answered
What is APLOMB?
APLOMB is the all-in-one system for GLP-1 side effects: four products — Facial Serum, Protein, Roots, and Steady — each built for one documented side effect of rapid weight loss on a GLP-1. No prescription required.
Do I need all four products?
No. Each product works on its own. Most women start with the one or two side effects they actually feel; the kits simply box the routine and price it better.
Will it work with my GLP-1?
Every product is made to sit alongside semaglutide, tirzepatide, and the other GLP-1s, and the rest of your routine. If a side effect is severe or sudden, talk to your prescriber.
How does the subscription work?
Subscription savings are shown and applied at checkout. Renewals ship every 30 days at the displayed subscription price. Pause or cancel anytime from your account, no phone call required.
What if it does not work for me?
Every order is backed by the 30-day money-back guarantee. Contact us within 30 days for a refund.
When will I feel or see a difference?
It depends on the side effect. Nausea support is usually felt within days. Hair and skin change on a slower calendar — shedding typically lags the weight loss by two to four months, so give it steady weeks.