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Support for the side effects of GLP-1 weight loss.

Aplomb makes targeted products for the side effects of GLP-1s: looser-looking skin, muscle loss, hair shedding, and nausea.

Start with the Essentials Kit Take the 60-second side-effect quiz
A woman in her kitchen with the four-product Aplomb system: Protein, Facial Serum, Roots, and Calm.
Third-party tested GMP-certified No prescription needed Works alongside your care
The four APLOMB products together: Facial Serum, Protein, Roots, and Calm.

Choose your kit.

Two ways to start: the two products almost everyone needs, or the complete four-product system.

The four APLOMB products together: Facial Serum, Protein, Roots, and Calm.
Essentials Kit · 2 products

30-day money-back guarantee if you don't like these products.

Each item remains a separate product with its own label and use case. Facial Serum is a topical cosmetic; Protein, Roots, and Calm are dietary supplements. Not evaluated by the FDA. Not intended to diagnose, treat, cure, or prevent any disease.

A solution for each side effect.

A woman holding the APLOMB Facial Serum at her vanity in warm light.

Facial Serum.

For the skin changes GLP-1 causes.

"I would be using this serum to tighten my skin even if I weren't on GLP-1s." Catherine, 55
A woman pouring an APLOMB Protein scoop into a shaker in a bright kitchen.

Protein.

For lean mass and muscle retention.

"I love that this is plant protein instead of whey protein because it's easier on my stomach." Jennifer, 38
A woman taking an APLOMB Roots gummy at her kitchen counter.

Roots.

For hair loss.

"I'm so relieved I don't have to worry about my hair thinning." Amber, 37
A woman with a cup of ginger tea and a jar of APLOMB Calm gummies.

Calm.

For nausea.

"The nausea became so much more manageable." Rebecca, 42

Every product also works on its own. Shop individually →

What clinicians are saying.

From the Cleveland Clinic, on hair thinning:
Your body can perceive weight loss as a stress. As this happens, it begins to hold on to resources for your vital organs.
Does Ozempic Cause Hair Loss?

What customers are saying.

Jennifer, 38 · on Protein:
I love that this is plant protein instead of whey protein because it's easier on my stomach.
Customer note
Catherine, 55 · on Facial Serum:
I would be using this serum to tighten my skin even if I weren't on GLP-1s.
Customer note
Amber, 37 · on Roots:
I'm so relieved I don't have to worry about my hair thinning.
Customer note
Rebecca, 42 · on Calm:
The nausea became so much more manageable.
Customer note

Start with Essentials.

Facial Serum and Calm cover the face and nausea, the two problems women tend to feel first.

Start with the Essentials Kit Compare the Complete System
Facial Serum · $65 Protein · $65 Roots · $39 Calm · $35
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    What we cite for the two-driver mechanism.

    Volume loss and the 9 to 16 week window (the volumetric half, what fillers address)

    The dermal-half evidence base (where the Facial Serum acts)

    No GLP-1-specific topical trials exist for this category. The peptide actives in this serum have evidence in general dermal-aging populations (Sederma, Li 2023). We extrapolate to the rapid-weight-loss cohort because the underlying biology, collagen loss from metabolic and nutritional stress, is mechanistically the same.

    What we cite for hair thinning on GLP-1s.

    Real-world incidence

    Why iron, D, and zinc, not biotin

    What we cite for nausea on GLP-1s.

    RCT incidence and duration

    Adjacent-population evidence base

    What we cite for lean-muscle loss on GLP-1s.

    Prevalence and mechanism

    Intervention evidence base